A community-based study of provirus load in human immunodeficiency virus (HIV) type 2-infected subjects was done in a rural village in Guinea-Bissau, HIV-2 provirus load varied considerably, with a geometric mean of 124.3 (95% confidence interval, 86.0-179.6) copies/105 CD4 cells, which is a level similar to that found in HIV-1 infection. Neither malaria parasitemia, active syphilis, or human T cell leukemia virus coinfection significantly influenced provirus load, nor did age. Eleven of 104 HIV-2-infected subjects had died after 3 years of follow-up; 9 of those who died had a high provirus load of ≥100 copies/105 CD4 cells and a relatively low CD4 cell percentage of <29%.
Bibliographical noteFunding Information:
Received 2 June 1995; revised 21 August 1995. Presented in part: X International Conference on AIDS/IV STD World Congress, Yokohama, Japan, 1994 (abstract PA0174). Informed consent was obtained from all subjects. The study protocol was approved by the Ethical Committee of the Medical Research Council Laboratories in Gambia and National AIDS Control Programme in Guinea-Bissau. Grant support: UK Medical Research Council AIDS Strategic Programme; Science and Technology for Development Programme of the European Community (TS3*-CT92-0051). Reprints or correspondence: Dr. Koya Ariyoshi, Medical Research Council Laboratories, P.O. Box 273, Banjul, Gambia, West Africa.
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