A continuum of HIV care describing mortality and loss to follow-up: a longitudinal cohort study

UK CHIC Study Steering Committee

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16 Citations (Scopus)


Background: The cross-sectional HIV care continuum is widely used to assess the success of HIV care programmes among populations of people with HIV and the potential for ongoing transmission. We aimed to investigate whether a longitudinal continuum, which incorporates loss to follow-up and mortality, might provide further insights about the performance of care programmes. Methods: In this longitudinal cohort study, we included individuals who entered the UK Collaborative HIV Cohort (CHIC) study between Jan 1, 2000, and Dec 31, 2004, and were linked to the national HIV cohort database (HIV and AIDS Reporting System). For each month during a 10 year follow up period, we classified individuals into one of ten distinct categories according to engagement in care, antiretroviral therapy (ART) use, viral suppression, loss to cohort follow-up and loss to care, and mortality, and assessed the proportion of person-months of follow-up spent in each stage of the continuum. 5 year longitudinal continuums were also constructed for three separate cohorts (baseline years of entry 2000–03, 2004–07, and 2008–09) to compare changes over time. Findings: We included 12 811 people contributing 1 537 320 person-months in our analysis. During 10 years of follow-up, individuals spent 811 057 (52·8%) of 1 537 320 person-months on ART. Of the 811 057 person-months spent on ART, individuals had a viral load of 200 copies per mL or less for 607 185 (74·9%) person-months. 10 years after cohort entry, 3612 (28·1%) of 12 811 individuals were lost to follow-up, 954 (26·4%) of whom had transferred to a non-CHIC UK clinic for care. By 10 years, 759 (5·9%) of 12 811 participants who entered the cohort had died. Loss to follow-up decreased and the proportion of person-months that individuals spent virally suppressed increased over calendar time. Interpretation: Loss to follow-up in HIV care programmes was high and rates of viral suppression were lower than previously reported. Complementary information provided by a longitudinal continuum might highlight areas for intervention along the HIV care pathway, however, transfers outside the cohort must be accounted for. Funding: Medical Research Council, UK.

Original languageEnglish
Pages (from-to)e301-e308
JournalThe Lancet HIV
Issue number6
Publication statusPublished - Jun 2018

Bibliographical note

Funding Information:
The UK CHIC Study is funded by the Medical Research Council (MRC), UK (grants G0000199, G0600337, G0900274, and M004236). The views expressed in this manuscript are those of the researchers and not necessarily those of the MRC. The research was funded by the National Institute for Health Research Health Protection Research Unit in Blood Borne and Sexually Transmitted Infections at University College London and in collaboration with the London School of Hygiene & Tropical Medicine in partnership with Public Health England. The views expressed in this publication are those of the authors and not necessarily those of the National Health Service, the National Institute for Health Research, or the Department of Health.

Funding Information:
SJ reports speaker fees from Gilead Sciences outside the submitted work. FB reports consultancy fees and conference support from Gilead Sciences. KP has been an advisory board member for ViiV Healthcare, for which she has received honoraria. CAS reports grants from the Medical Research Council and the National Institute for Health Research during the conduct of the study; and personal fees from Gilead Sciences, ViiV Healthcare, and Janssen-Cilag outside the submitted work. VD, AH, and TH declare no competing interests.

Publisher Copyright:
© 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license


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