A fatal case of disseminated aspergillosis caused by a non-sporulating strain of Aspergillus fumigatus

M. E. Callister, M. J. Griffiths, A. G. Nicholson, A. Leonard, Elizabeth Johnson, M. I. Polkey, J. R. Kerr*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

This report describes the case of a 38 year old pregnant woman with fatal disseminated aspergillosis and multiorgan failure, which was preceded by a long history of allergic bronchopulmonary aspergillosis. Postmortem revealed massive infarction and abscess formation in both lungs. Histology revealed a focal granutomatous response. Fungal infiltration with areas of necrosis were also seen in the liver, spleen, and paratracheal, mediastinal, para-aortic, and hilar lymph nodes. Culture of tissue samples produced a non-sporulating, beige coloured fungus that developed green pigmentation only after three weeks of incubation. Nucleotide sequencing of the D1-D2 region of the large ribosomal subunit revealed 100% homology with Aspergillus fumigatus. Minimum inhibitory concentrations for amphotericin B and itraconazole were both 0.25 mg/litre (susceptible). Further work is urgently required to determine the prevalence of such non-sporulating strains and their relevance to clinical infection.

Original languageEnglish
Pages (from-to)991-992
Number of pages2
JournalJournal of Clinical Pathology
Volume57
Issue number9
DOIs
Publication statusPublished - Sep 2004

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