A population based study of variations in operation rates for breast cancer, of comorbidity and prognosis at diagnosis: Failure to operate for early breast cancer in older women

T. Bates, T. Evans, C. Lagord, I. Monypenny, Olive Kearins, Gillian Lawrence

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Abstract Background Older women are less likely to have surgery for operable breast cancer. This population-based study examines operation rates by age and identifies groups which present with early or late disease. Methods 37 000 cancer registrations for 2007 were combined with Hospital Episode Statistics comorbidity data for England. Operation rates were examined by age, ethnicity, deprivation, comorbidity, screen-detection, tumour size, grade and nodal status. Early and late presentation were correlated with Nottingham Prognostic Index (NPI) groups and tumour size. Results The proportion of women not having surgery increased from 7-10% at ages 35-69 to 82% from age 90. From age 70, the proportion not having surgery rose by an average of 3.1% per year of age. Women with a Charlson Comorbidity Index score of ≥1 (which increased with age), with tumours >50 mm or who were node positive, were less likely to have surgery. Although women aged 70-79 were more likely to have larger tumours, their tumours were also more likely to have an excellent or good NPI (p < 0.001). Good prognosis tumours were more likely to be screen-detected, and less likely in women aged 0-39, the deprived and certain ethnic groups (p < 0.02). Conclusions From age 70 there is an increasing failure to operate for breast cancer. Younger women and certain ethnic groups presented with more advanced tumours. Older women had larger tumours which were otherwise of good prognosis, and this would not account for the failure to operate which may in part be related to comorbidity in this age group.

Original languageEnglish
Article number3846
Pages (from-to)1230-1236
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume40
Issue number10
DOIs
Publication statusPublished - 1 Oct 2014

Keywords

  • Age factors
  • Breast neoplasm
  • Comorbidity
  • Data collection
  • Ethnic groups
  • Socioeconomic status
  • Surgery

Fingerprint

Dive into the research topics of 'A population based study of variations in operation rates for breast cancer, of comorbidity and prognosis at diagnosis: Failure to operate for early breast cancer in older women'. Together they form a unique fingerprint.

Cite this