A rapid diagnostic test for ebola virus disease

Catherine Houlihan, Colin Brown

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Diagnostic methods to detect Ebola Virus Disease (EVD) in West Africa and worldwide have been limited to molecular techniques, specifically detecting viral RNA by reverse transcription polymerase chain reaction in bodily fluids. A rapid diagnostic test (RDT) with high sensitivity would allow the identification and isolation of infected and infectious persons, thus preventing onward spread. Having RDTs available in remote or rural areas at risk of EVD could dramatically reduce the time from its introduction into a community to recognition of EVD and instigation of a public health response. This would limit subsequent people from becoming infected. Seven lateral flow assays are in various stages of validation and several look promising. Furthermore, closed system nucleic acid amplification tests offer exciting promise with minimal reagent and power needs, and minimal operator skill requirements. FilmArray methods offer the possibility of diagnosing multiple pathogens from a single sample.

Original languageEnglish
Title of host publicationRevolutionizing Tropical Medicine
Subtitle of host publicationPoint-of-Care Tests, New Imaging Technologies and Digital Health
Publisherwiley
Pages202-212
Number of pages11
ISBN (Electronic)9781119282686
ISBN (Print)9781119282648
DOIs
Publication statusPublished - 31 May 2019

Keywords

  • Developing countries
  • Developing nations
  • Developing world
  • Diseases in the tropics
  • Ebola
  • Ebola virus disease
  • LMICs
  • Low-to middle-income countries
  • POC
  • Point-of-care testing
  • Rapid diagnostic tests
  • RDTs
  • Tropical diseases
  • Viral disease

Fingerprint

Dive into the research topics of 'A rapid diagnostic test for ebola virus disease'. Together they form a unique fingerprint.

Cite this