A survey of lymphocyte chromosomal damage in Slovenian workers exposed to occupational clastogens

K. Al-Sabti*, D. C. Lloyd, Alan Edwards, P. Stegnar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Assays for sister-chromatid exchanges (SCE), unstable chromosome and chromatid aberrations and micronuclei were performed on blood lymphocytes from persons exposed protractedly to radiation or chemical hazards in the workplace. There was a general tendency with all endpoints examined for the yields to increase with years of working in the industry. This was especially marked for SCE. By comparison with a control group of administrative workers the levels of damage were higher, usually significantly so, in the occupational groups. These comprised workers at a nuclear research reactor, a hospital diagnostic X-ray department, a coal mine and a mercury ore mine.

Original languageEnglish
Pages (from-to)215-223
Number of pages9
JournalMutation Research/Genetic Toxicology
Volume280
Issue number3
DOIs
Publication statusPublished - Sep 1992

Bibliographical note

Funding Information:
We wish to express our gratitude to Dr. A. Kobal and E. Nanot from the Idrija mine, B. Stropnik from the Velenja mine and J. Zalar from Maribor Hospital for provision of blood for this study. This work is part of a project supported by the Ministry of Science, Research and Technology, Republic of Slovenia.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

  • Cytogenetic monitoring
  • Human lymphocytes
  • Occupational clastogens

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