Accelerating control of pertussis in England and Wales

Helen Campbell*, Gayatri Amirthalingam, Nicholas Andrews, Norman Fry, Robert George, Timothy Harrison, Elizbeth Miller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)

Abstract

Results of an accelerated pertussis vaccination schedule introduced in 1990 for infants in England and Wales were examined. Earlier scheduling and sustained high vaccine coverage resulted in fewer reported cases of pertussis among infants, reinforcing the World Health Organization drive for on-time completion of the infant vaccination schedule. As determined by using the screening method, the first dose of vaccine was 61.7% effective in infants <6 months of age, and effectiveness increased with subsequent doses. Three doses of a good whole-cell pertussis vaccine were 83.7% effective in children 10-16 years of age; a preschool booster vaccination further reduced pertussis incidence in children <10 years of age. As in other industrialized countries, surveillance data during 1998-2009 showed that pertussis in England and Wales mainly persists in young infants (i.e., <3 months of age), teenagers, and adults. Future vaccine program changes may be beneficial, but additional detail is required to inform such decisions.

Original languageEnglish
Pages (from-to)38-47
Number of pages10
JournalEmerging Infectious Diseases
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 2012

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