An evaluation of gentamicin susceptibility of Neisseria gonorrhoeae isolates in Europe

Stephanie Chisholm, Nerteley Quaye, Michelle Cole, Hans Fredlund, Steen Hoffmann, Jørgen Skov Jensen, Marita J. van de Laar, Magnus Unemo, Catherine Ison*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

Objectives: The emergence of decreased susceptibility to third-generation, extended-spectrum cephalosporins in Neisseria gonorrhoeae and associated treatment failures highlights the need to consider alternatives for future therapeutic use, such as gentamicin. Methods: The three laboratories surveying gonococcal antimicrobial susceptibility as part of the European Network for Sexually Transmitted Infections Surveillance compared agar dilution and Etest to determine gentamicin MICs and performed the first survey of gentamicin susceptibility on 1366 gonococcal isolates from 17 European Union/European Economic Area (EU/EAA) countries in 2009. Results: Sentinel surveillance of gentamicin susceptibility showed that 95% of European isolates were within a narrow MIC range (4-8 mg/L), with 79% showing an MIC of 8 mg/L. Most countries showed little variation, but wider MIC ranges were observed in Greece (1-16 mg/L) and France, Norway and Sweden (2-16 mg/L). While MICs for both methods generally differed by just one doubling dilution, they were lower by Etest. Conclusions: This is the first reported evidence that the European gonococcal population susceptibility to gentamicin is similar to that reported in other world regions. Clinical trials to evaluate the therapeutic efficacy of gentamicin may be warranted.

Original languageEnglish
Article numberdkq476
Pages (from-to)592-595
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume66
Issue number3
DOIs
Publication statusPublished - Mar 2011

Bibliographical note

Funding Information:
The European Network for STIs Surveillance, including the STI Microbiology Programme, is funded by the ECDC.

Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.

Keywords

  • Agar dilution
  • Antimicrobial resistance
  • Etest
  • Sentinel surveillance

Fingerprint

Dive into the research topics of 'An evaluation of gentamicin susceptibility of Neisseria gonorrhoeae isolates in Europe'. Together they form a unique fingerprint.

Cite this