An outbreak of multidrug-resistant Pseudomonas aeruginosa in a burns service in the North of England: challenges of infection prevention and control in a complex setting

V. Decraene*, Samuel Ghebrehewet, E. Dardamissis, R. Huyton, K. Mortimer, D. Wilkinson, K. Shokrollahi, S. Singleton, B. Patel, Jane Turton, Peter Hoffman, Richard Puleston

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Background: Burns patients are at high risk of nosocomial infection, and Pseudomonas aeruginosa is one of the most common causes of wound and systemic infections resulting in significant morbidity and mortality in burns patients. Aim: To describe an outbreak of multidrug-resistant P. aeruginosa (MDR-Pa) at a specialist burns service and highlight the challenges in identifying the reservoir of infection despite extensive epidemiological, microbiological, and environmental investigations. Methods: Multi-disciplinary outbreak control investigation. Findings: Following an inter-hospital transfer of a burns patient from another country, an admission screen revealed that the patient was colonized with MDR-Pa. Subsequently nine more patients contracted MDR-Pa in the period from November 2015 to September 2017. Given the relatively long gap between confirmation of the index and subsequent cases, it was not possible to identify with certainty the reservoirs and mechanisms of spread of infection, although contamination of the burns service environment and equipment are likely to be contributory factors. Conclusion: Preventing infection transmission in specialist burns services is highly challenging, and it may not always be possible to identify and eradicate the reservoirs of infection for P. aeruginosa outbreaks. Our study supports the literature, providing additional evidence that inanimate, common contact surfaces play an important role in nosocomial transmission of P. aeruginosa. These surfaces should either be decontaminated efficiently between patient contacts or be single patient use. Enhanced vigilance is crucial, and, with strict adherence to infection prevention and control procedures, it is possible to reduce the risk of acquisition and spread of infection in patients.

Original languageEnglish
Pages (from-to)e239-e245
JournalJournal of Hospital Infection
Volume100
Issue number4
DOIs
Publication statusPublished - Dec 2018

Bibliographical note

Funding Information:
We would like to thank the IPC team, especially K. Allen, Valya W. and S. Redfern; the burns and intensive care staff; and the nursing, medical, management and microbiology laboratory staff of the local hospital. We also extend our thanks to M. Cook (PHE North of England, Knowledge & Library Services) for his support with the literature search, V. Watts and P. Cleary (PHE Field Epidemiology Service North West) for their help with data management and visualization, J. Walker (PHE Water Microbiology and Decontamination, Porton Down) and E. Kaczmarski (PHE Public Health Laboratory, Manchester Royal Infirmary) for their support in the management of the outbreak and laboratory staff in the Antimicrobial Resistance and Healthcare Associated Infections Reference Unit for typing and antibiotic susceptibility investigations.

Publisher Copyright:
© 2018

Keywords

  • Burns service
  • Environmental investigations
  • Outbreak
  • Pseudomonas aeruginosa

Fingerprint

Dive into the research topics of 'An outbreak of multidrug-resistant Pseudomonas aeruginosa in a burns service in the North of England: challenges of infection prevention and control in a complex setting'. Together they form a unique fingerprint.

Cite this