Antibiotic surgical prophylaxis increases nasal carriage of antibiotic-resistant staphylococci

Claire L. McMurray*, Katherine J. Hardy, Neville Verlander, Peter Hawkey

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Staphylococci are a significant cause of hospital-acquired infection. Nasal carriage of Staphylococcus aureus is an important risk factor for infection in surgical patients and coagulase-negative staphylococci (CNS) are a major cause of prosthetic joint infections. The impact that antibiotic surgical prophylaxis has on the nasal carriage of staphylococci has not been studied. Daily nasal swabs were taken from 63 patients who received antibiotic surgical prophylaxis and 16 patients who received no antibiotics. Total aerobic bacterial count, S. aureus and CNS were enumerated by culture from nasal swabs. Representative isolates were typed by staphylococcal interspersed repeat units (SIRU) typing and PFGE, and MICs to nine antibiotics were determined. After antibiotic administration, there was a reduction in S. aureus counts (median 22.3 log10c.f.u. ml-1) in 64.0 % of S. aureus carriers, compared with only a 0.89 log10c.f.u. ml-1 reduction in 75.0 % of S. aureus carriers who did not receive antibiotics. A greater increase in the nasal carriage rate of meticillin-resistant CNS was observed after antibiotic surgical prophylaxis compared with hospitalization alone, with increases of 16.4 and 4.6 %, respectively. Antibiotic-resistant S. epidermidis carriage rate increased by 16.6 % after antibiotic administration compared with 7.5 % with hospitalization alone. Antibiotic surgical prophylaxis impacts the nasal carriage of both S. aureus and CNS.

Original languageEnglish
Pages (from-to)1489-1495
Number of pages7
JournalJournal of Medical Microbiology
Volume64
Issue number12
DOIs
Publication statusPublished - Dec 2015

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Publisher Copyright:
© 2015 The Authors.

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

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