The safety and immunogenicity of two conjugate Haemophilus influenzae type B (Hib) vaccines administered either mixed with, or in separate limbs to, a whole-cell DTP vaccine, was compared in infants vaccinated at 2, 3 and 4 months of age. Antibody titres to purified polyribosylribitol phosphate, diphtheria, and to pertussis antigens between infants who received the Hib and DPT vaccines in separate limbs or in the same limbs were similar (P>0.1) while antibody titres to tetanus toxoid were higher in the later group (P<0.05). This study demonstrated that both Hib vaccines can be mixed with whole-cell DTP vaccine without reducing immunogenicity of either vaccine or increasing the incidence of adverse reactions.
Bibliographical noteFunding Information:
We would like to thank Dr Keith Cartwright and the study nurses in Gloucester and Hertfordshire. The study was funded by the Department of Health, Lederle-Praxis and Pasteur-Merieux. CKF receives a salary from the National Health and Medical Research Council of Australia.
- Haemophilus influenzae conjugate vaccine