Antibody responses and symptoms after DTP and either tetanus or diphtheria Haemophilus influenzae type B conjugate vaccines given for primary immunisation by separate or mixed injection

Norman T. Begg, Elizbeth Miller, Christopher K. Fairley*, Helen M. Chapel, Helen Griffiths, Pauline A. Waight, L. A.Edward Ashworth

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

The safety and immunogenicity of two conjugate Haemophilus influenzae type B (Hib) vaccines administered either mixed with, or in separate limbs to, a whole-cell DTP vaccine, was compared in infants vaccinated at 2, 3 and 4 months of age. Antibody titres to purified polyribosylribitol phosphate, diphtheria, and to pertussis antigens between infants who received the Hib and DPT vaccines in separate limbs or in the same limbs were similar (P>0.1) while antibody titres to tetanus toxoid were higher in the later group (P<0.05). This study demonstrated that both Hib vaccines can be mixed with whole-cell DTP vaccine without reducing immunogenicity of either vaccine or increasing the incidence of adverse reactions.

Original languageEnglish
Pages (from-to)1547-1550
Number of pages4
JournalVaccine
Volume13
Issue number16
DOIs
Publication statusPublished - 1995

Bibliographical note

Funding Information:
We would like to thank Dr Keith Cartwright and the study nurses in Gloucester and Hertfordshire. The study was funded by the Department of Health, Lederle-Praxis and Pasteur-Merieux. CKF receives a salary from the National Health and Medical Research Council of Australia.

Keywords

  • Haemophilus influenzae conjugate vaccine

Fingerprint

Dive into the research topics of 'Antibody responses and symptoms after DTP and either tetanus or diphtheria Haemophilus influenzae type B conjugate vaccines given for primary immunisation by separate or mixed injection'. Together they form a unique fingerprint.

Cite this