Antipneumococcal seroprevalence and pneumococcal carriage during a meningococcal epidemic in Burkina Faso, 2006

Seydou Yaro, Berthe Marie Njanpop-Lafourcade, Aly Drabo, Régina S. Idohou, Sita S. Kroman, Oumarou Sanou, Yves Traoré, Lassana Sangaré, Serge P. Diagbouga, Jean Louis Koeck, Raymond Borrow, Bradford D. Gessner*, Judith E. Mueller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background. To better understand the high incidence of pneumococcal meningitis in the African meningitis belt, we conducted a pneumococcal seroprevalence study during a meningococcal meningitis epidemic in Western Burkina Faso, March 2006.Methods. In 3 villages experiencing epidemics, we included 624 healthy persons (1-39 years) by cluster sampling. We determined pneumococcal serum immunoglobulin G (IgG) antibody concentrations against 12 serotypes contained in 13-valent pneumococcal conjugate vaccine, and evaluated determinants for IgG ≥ 0.35 μg/mL by multivariate logistic regression.Results. The percentage of subjects with serotype-specific IgG concentrations ≥0.35 μg/mL increased with age and was similar for the different serotypes: it was 20%-43% among 1-4-year-olds and 56%-90% among 20-39-year-olds. Prevalence of IgG ≥ 0.35 μg/mL against serotype 1 was up to 71% after age 10 years. During multivariate analyses, determinants of IgG concentrations ≥0.35 μg/mL varied by serotype; for 5 and 6 serotypes, respectively, female sex (around 2-fold increased odds) and cigarette smoking (about 5-fold reduced odds) predicted elevated titers.Conclusions. Despite a substantially higher historical pneumococcal meningitis incidence in Burkina Faso, the general population has an antibody seroprevalence against 12 pneumococcal serotypes similar to that reported from the United Kingdom. The role of putatively protective antibody seroprevalence in preventing pneumococcal meningitis in the meningitis belt requires more thorough evaluation.

Original languageEnglish
Pages (from-to)1241-1250
Number of pages10
JournalJournal of Infectious Diseases
Volume209
Issue number8
DOIs
Publication statusPublished - 15 Apr 2014

Bibliographical note

Funding Information:
Potential conflicts of interest. B. M. N. L., R. S. I., S. S. K., O. S., and B. D. G. work, and J. E .M. until recently worked, for the Agence de Méde-cine Préventive, which receives unrestricted funding from Sanofi Pasteur, and grant specific funding from Crucell, Glaxo-Smith-Kline, Merck, Novar-tis, Pfizer, and Sanofi Pasteur. R. B. has performed contract research on behalf of the Health Protection Agency, funded by Pfizer, Novartis Vaccines, Baxter Bioscience, GlaxoSmithKline, Sanofi Pasteur, Sanofi Pasteur MSD, Alexion Pharmaceuticals Inc, and Merck. All other authors do not have any commercial or other association that might pose a conflict of interest.

Funding Information:
Financial support. This work was supported by Sanofi Pasteur, a producer of pneumococcal vaccines (contract: MEN8).

Keywords

  • Africa
  • Burkina Faso
  • Neisseria meningitides
  • Streptococcus pneumoniae
  • asymptomatic infection
  • immunity
  • meningitis
  • meningitis belt
  • seroprevalence

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