Avidity maturation following vaccination with a meningococcal recombinant hexavalent PorA OMV vaccine in UK infants

Emma Longworth, Raymond Borrow, David Goldblatt, Paul Balmer, Maureen Dawson, Nicholas Andrews, Elizbeth Miller, Keith Cartwright

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

To date, there are no data assessing the utility of avidity indices as a surrogate marker for the induction of immunological memory following meningococcal serogroup B outer membrane vesicle (OMV) vaccination. We studied infants who had been immunized with three doses of a recombinant hexavalent PorA OMV vaccine at ages 2-4 months, together with a fourth dose at age 12-18 months. A control group had received a single dose of the same vaccine at age 12-18 months. As previously reported, serum bactericidal antibody (SBA) titres increased after each of the first three doses, with a significant increase observed from 6 months post third dose to 1 month post fourth dose. The geometric mean avidity indices (GMAI), against strain H44/76 OMVs, increased from 1 month post first dose to 1 month post third dose. Significant increases in GMAI were observed at 6 months post third dose and again following the fourth dose. At 32-42 months of age, though the SBA titres had returned to post first dose levels, the GMAI remained elevated. No increase in avidity was observed in the control group. Antibody avidity indices are useful laboratory markers for the priming of immunological memory following vaccination with meningococcal serogroup B OMV vaccines.

Original languageEnglish
Pages (from-to)2592-2596
Number of pages5
JournalVaccine
Volume20
Issue number19-20
DOIs
Publication statusPublished - 7 Jun 2002
Externally publishedYes

Keywords

  • Avidity
  • Neisseria meningitidis
  • Vaccine

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