Barrett's columnar-lined oesophagus: Demographic and lifestyle associations and adenocarcinoma risk

P. A.C. Gatenby, C. P.J. Caygill, J. R. Ramus, Andre Charlett, A. Watson

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Objectives: Lifestyle and demographic risk factors for the development of oesophageal adenocarcinoma developing from columnar-lined oesophagus are not well defined. Methods: Demographic and lifestyle factors, endoscopy and histology reports were extracted from 1,761 subjects from seven UK centres. The associations of columnar-lined oesophagus with demographic and lifestyle factors and the development of adenocarcinoma were examined. Results: 5.5% of patients had prevalent adenocarcinoma (more common in males, older patients, patients diagnosed earlier in the cohort and current or recent smokers). Adenocarcinoma incidence was 23 patients in 3,912 years or 0.59% per annum. Only increased age at diagnosis correlated with an increased risk of incident adenocarcinoma. There was no association with obesity or alcohol history. Conclusions: Oesophageal adenocarcinoma occurs more commonly in older patients and is more frequent in males than females. Once columnar-lined oesophagus had been diagnosed, there were no other demographic or lifestyle factors which were predictive of the development of incident adenocarcinoma in this cohort.

Original languageEnglish
Pages (from-to)1175-1185
Number of pages11
JournalDigestive Diseases and Sciences
Volume53
Issue number5
DOIs
Publication statusPublished - May 2008

Bibliographical note

Funding Information:
Acknowledgements We are indebted to the registrants and registering centres (see Appendix 1) who made this study possible and to Dr. R. Fitzgerald for assistance in the project design and manuscript preparation. We are grateful to the following for financial support: the Barrett’s Oesophagus Foundation, the Wexham Gastrointestinal Trust, the Childwick Trust, the R. L. St. J. Harmsworth Memorial Research Fund and the David and Frederick Barclay Foundation.

Keywords

  • Adenocarcinoma
  • Alcohol consumption
  • Barrett's oesophagus
  • Epidemiology
  • Health behaviour
  • Obesity
  • Smoking

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