Burden of hospital admissions caused by respiratory syncytial virus (RSV) in infants in England: A data linkage modelling study

R. M. Reeves, P. Hardelid, N. Panagiotopoulos, M. Minaji, F. Warburton, Richard Pebody

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Objectives: Current national estimates of respiratory syncytial virus (RSV)-associated hospital admissions are insufficiently detailed to determine optimal vaccination strategies for RSV. We employ novel methodology to estimate the burden of RSV-associated hospital admissions in infants in England, with detailed stratification by patient and clinical characteristics. Methods: We used linked, routinely collected laboratory and hospital data to identify laboratory-confirmed RSV-positive and RSV-negative respiratory hospital admissions in infants in England, then generate a predictive logistic regression model for RSV-associated admissions. We applied this model to all respiratory hospital admissions in infants in England, to estimate the national burden of RSV-associated admissions by calendar week, age in weeks and months, clinical risk group and birth month. Results: We estimated an annual average of 20,359 (95% CI 19,236-22,028) RSV-associated admissions in infants in England from mid-2010 to mid-2012. These admissions accounted for 57,907 (95% CI 55,391-61,637) annual bed days. 55% of RSV-associated bed days and 45% of RSV-associated admissions were in infants <3 months old. RSV-associated admissions peaked in infants aged 6 weeks, and those born September to November. Conclusions: We employed novel methodology using linked datasets to produce detailed estimates of RSV-associated admissions in infants. Our results provide essential baseline epidemiological data to inform future vaccine policy.

Original languageEnglish
Pages (from-to)468-475
Number of pages8
JournalJournal of Infection
Volume78
Issue number6
DOIs
Publication statusPublished - Jun 2019

Keywords

  • Bronchiolitis
  • Data linkage
  • Hospital admissions
  • Infants
  • Pneumonia
  • RSV
  • Respiratory syncytial virus
  • Respiratory tract infection

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