Can better prescribing turn the tide of resistance?

David Livermore*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

85 Citations (Scopus)


In the wake of concerns about the level of antibiotic resistance, governments worldwide are pressing for reduced antibiotic use, hoping thereby to reverse resistance trends. Is success likely? The evidence is mixed, and expectations should be tempered by the growing realization that many resistant bacteria are biologically fit, making them difficult to displace. If resistance is unlikely to be reduced significantly by changing prescription practices, how can clinicians outpace increased resistance, particularly when much of 'big pharma' is abandoning antibiotic development?

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalNature Reviews Microbiology
Issue number1
Publication statusPublished - Jan 2004


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