Chromosomal abnormalities in neutron-induced acute myeloid leukemias in CBA/H mice

Simon Bouffler, Emmy I.M. Meijne, Rene Huiskamp, Roger Cox

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Acute myeloid leukemias (AMLs) induced in CBA/H mice by 1 MeV fission neutrons have been examined for chromosomal abnormalities by G-band analysis. In common with X-ray- and α-particle-induced AMLs in CBA/H mice, more than 90% (16/17) of the myeloid leukemias had chromosome 2 abnormalities, in this case, all interstitial deletions. Chromosome 2 breakpoints were not wholly consistent, but clustering in three specific G-band regions was observed. Very distal (H-region) breakpoints were more common in the neutron AMLs than in X-ray- or α-particle-induced leukemias. These data indicate that neutron- induced AMLs in CBA/H mice are not characterized by a specific chromosome deletion but that a variety of chromosome 2 deletion types are associated with the disease. Trisomy of chromosome 1 (12.5% AMLs) and aneusomy of chromosomes 6 (31% AMLs) and Y (37.5% AMLs) were noted. While chromatid breakage was observed occasionally in neutron-induced AML, no clear indications of persistent chromosomal instability or high levels of stable chromosomal change were apparent.

Original languageEnglish
Pages (from-to)349-352
Number of pages4
JournalRadiation Research
Volume146
Issue number3
DOIs
Publication statusPublished - Sep 1996

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