Chromosomal analysis of peripheral lymphocytes of patients before and after radiation synovectomy with samarium-153 particulate hydroxyapatite

E. K. O'Duffy, F. J. Oliver, S. J. Chatters, H. Walker*, David Lloyd, J. C.W. Edwards, P. J. Ell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Objective. Radiation synovectomy may be indicated for the treatment of chronic synovitis. A number of factors may affect its current use, including availability, limited evidence for its efficacy compared to intra-articular glucocorticoid, and concerns regarding the potential long-term effects of radiation exposure, particularly in younger patients. Specific chromosome-type abnormalities in peripheral lymphocytes can be useful indicators of whole-body radiation exposure. The frequency of these aberrations has been shown to increase in patients who have had radiation synovectomy using yttrium-90 by up to five times compared to baseline levels. Samarium-153 particulate hydroxyapatite (Sm-153 PHYP) is a new radiopharmaceutical currently on trial which appears to have less extra-articular leakage than yttrium-90 compounds. The aim of this study was to identify any increase in specific chromosome-type abnormalities, using published criteria, in patients following Sm-153 PHYP synovectomy of the knee. The 10 patients (five men, five women) in whom the analyses were performed had a mean age of 47 yr (range 28-70 yr). Results. There was no increase in scored chromosome-type abnormalities after Sm-153 PHYP synovectomy. Conclusion. This study further supports the relative safety of Sm-153 PHYP compared to other radiopharmaceuticals.

Original languageEnglish
Pages (from-to)316-320
Number of pages5
JournalRheumatology
Volume38
Issue number4
DOIs
Publication statusPublished - Apr 1999

Keywords

  • Chromosome
  • Radiation synovectomy

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