Chromosome aberration dosimetry using human lymphocytes in simulated partial body irradiation

David Lloyd*, R. J. Purrott, G. W. Dolphin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

The effect of X-irradiation on the yield of transformed cells in culture has been studied in human peripheral blood lymphocytes. Aberration yields are obtained for mixed cultures prepared from equal numbers of normal and irradiated lymphocytes and from pure cultures of irradiated cells. Comparison of data from these two types of culture show that the observed yield ranges from 90% of the expected at 50 rad to 11% at 700 rad. Poisson analysis demonstrates that for all doses, cells with high levels of chromosome structural damage are not selectively eliminated.

Original languageEnglish
Article number007
Pages (from-to)421-431
Number of pages11
JournalPhysics in Medicine and Biology
Volume18
Issue number3
DOIs
Publication statusPublished - 1973

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