Chronic Hepatitis E as a cause for cryptogenic cirrhosis in HIV

Gurmit K. Jagjit Singh, Samreen Ijaz, Neesha Rockwood, Simon P. Farnworth, Emma Devitt, Mark Atkins, Richard Tedder, Mark Nelson

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56 Citations (Scopus)

Abstract

Chronic Hepatitis E infection (HEV) is reported in immunocompromised patients. A 45-year-old HIV-infected man had no cause found for a persistent transaminitis which predated commencement of antiretroviral therapy. Hepatic elastography and liver biopsy revealed cirrhosis. In 2010, he tested positive for HEV IgM/IgG antibodies. Plasma HEV RNA was detected. Archived samples revealed HEV viraemia since 2000. A 24-week course of pegylated interferon was commenced and HEV RNA became undetectable at week 4 until week 27 post treatment cessation. Chronic HEV infection should be considered in HIV patients as a cause for unexplained transaminitis and cryptogenic liver cirrhosis.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalJournal of Infection
Volume66
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • Hepatitis E
  • HIV
  • Immunosuppression
  • Liver
  • Pegylated interferon
  • Transaminitis

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