Ciprofloxacin resistance in Neisseria gonorrhoeae in England and Wales in 2002

Kevin Fenton*, Catherine Ison, Alan Johnson, Elizabeth Rudd, Mehnam Soltani, Iona Martin, Thomas Nichols, David M. Livermore

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

87 Citations (Scopus)


The Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP) monitors trends in antimicrobial resistance in consecutive gonococcal isolates from 26 genitourinary medicine clinics in England and Wales. In 2002, 2204 gonococcal isolates were tested, and the overall prevalence of ciprofloxacin resistance (minimum inhibitory concentration ≥1 mg/L) was 9.8%, compared with 3.1% in 2001 and 2.1% in 2000. Between 2001 and 2002, prevalence of ciprofloxacin resistance increased two to three-fold, irrespective of recent sexual contact overseas, sex, or residence within or outside of London. These findings suggest that national and local treatment guidelines need to be reviewed urgently.

Original languageEnglish
Pages (from-to)1867-1869
Number of pages3
JournalThe Lancet
Issue number9372
Publication statusPublished - 31 May 2003

Bibliographical note

Funding Information:
GRASP is a collaborative initiative between surveillance, microbiology, and genitourinary physicians and specialists. We thank the collaborating laboratories and clinics for their ongoing involvement in the programme and Alan Herring and Andrew Turner of the former Genitourinary Infections Reference Laboratory (GUIRL) in Bristol, who were previous partners in this programme and were involved in the collection of isolates in the 2002 collection. GRASP is funded by a grant from the Department of Health, England. The sponsor had no role in study design, data collection, data analysis, data interpretation, or in the writing of this report.


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