Clinically targeted screening for congenital CMV - Potential for integration into the National Hearing Screening Programme

S. Kadambari, S. Luck, Adrian Davis, E. J. Williams, J. Berrington, P. D. Griffiths, M. Sharland

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

Screening for a condition should only be undertaken if certain strict criteria are met. Congenital CMV (cCMV) is a leading cause of sensorineuronal hearing loss (SNHL) and meets many of these criteria, but is not currently screened for in the UK. Ganciclovir reduces CMV-induced progressive SNHL if treatment is begun in the first month of life. The Newborn Hearing Screening Programme (NHSP) has been shown to identify SNHL at the earliest possible age. The potential of integrating screening for cCMV into the NHSP is discussed to consolidate the link between screening, early diagnosis and management. Conclusion: The early diagnosis and treatment of cCMV may prevent a small proportion of late SNHL. In the absence of any screening programme, we provide evidence that clinically targeted screening through the NHSP is a potential option in the UK, enhancing the diagnostic pathway and enabling appropriate early treatment to reduce long-term morbidity.

Original languageEnglish
Pages (from-to)928-933
Number of pages6
JournalActa Paediatrica, International Journal of Paediatrics
Volume102
Issue number10
DOIs
Publication statusPublished - Oct 2013

Keywords

  • Congenital CMV
  • Screening
  • Sensorineural hearing loss

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