Conclusions and future perspectives: Botulinum neurotoxins as paradigms for development of microbial effector-derived drugs

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The transformation of botulinum neurotoxin (BoNT) from a feared poison to a life-improving drug treatment is an extraordinary demonstration of the powers of biological molecules. The exceptional properties of bacterial effector molecules as demonstrated by BoNT offer both a library of molecules for the development of future therapies and important lessons for their identification and use. This chapter will explore the frontiers of BoNT-based therapies and attempt to use BoNT as a paradigm for the development of therapies that exploit the diversity of pathogen function.

Original languageEnglish
Title of host publicationTreatments from Toxins
Subtitle of host publicationThe Therapeutic Potential of Clostridial Neurotoxins
PublisherCRC Press
Pages255-279
Number of pages25
ISBN (Electronic)9781420004151
ISBN (Print)0849327091, 9780849327094
Publication statusPublished - 1 Jan 2006

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