The transformation of botulinum neurotoxin (BoNT) from a feared poison to a life-improving drug treatment is an extraordinary demonstration of the powers of biological molecules. The exceptional properties of bacterial effector molecules as demonstrated by BoNT offer both a library of molecules for the development of future therapies and important lessons for their identification and use. This chapter will explore the frontiers of BoNT-based therapies and attempt to use BoNT as a paradigm for the development of therapies that exploit the diversity of pathogen function.
|Title of host publication||Treatments from Toxins|
|Subtitle of host publication||The Therapeutic Potential of Clostridial Neurotoxins|
|Number of pages||25|
|ISBN (Print)||0849327091, 9780849327094|
|Publication status||Published - 1 Jan 2006|