Correlation of group C meningococcal conjugate vaccine response with B- and T-Lymphocyte activity

James B. Wing, Lynne Smart, Ray Borrow, Jamie Findlow, Helen Findlow, Andrew Lees, Robert C. Read, Andrew W. Heath

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Despite the success of conjugate vaccination against meningococcal group C (MenC) disease, post-vaccination, some individuals still exhibit rapid waning of initially protective bactericidal antibody levels. The mechanism of this relative loss of humoral protection remains undetermined. In this report we have investigated the relationship between T- and B-cell activation and co-stimulation and the loss of protective antibody titers. We have found that healthy volunteers who lose protective MenC antibody levels one year after receipt of glycoconjugate vaccine exhibit no detectable cellular defect in polyclonal B- or T-cell activation, proliferation or the B-memory pool. This suggests that the processes underlying the more rapid loss of antibody levels are independent of defects in either initial T- or B-cell activation.

Original languageEnglish
Article numbere31160
JournalPLoS ONE
Volume7
Issue number2
DOIs
Publication statusPublished - 8 Feb 2012

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