Cost Effectiveness of Human Papillomavirus Vaccination for Men Who have Sex with Men; Reviewing the Available Evidence

Didik Setiawan, Abrham Wondimu*, Kohjun J. Ong, Albert Jan Van Hoek, Maarten J. Postma

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Background: Men who have sex with men require special attention for human papillomavirus vaccination given elevated infection risks and the development of, in particular, anal cancer. Objective: Our purpose was to review the cost effectiveness of human papillomavirus vaccination for both currently vaccine-eligible and non-eligible individuals, particularly the men-who-have-sex-with-men population, and synthesize the available evidence. Methods: We systematically searched for published articles in two main databases (PubMed and EMBASE). Screening and data extraction were performed by two independent reviewers. The risk of bias was assessed using a validated instrument (Bias in Economic Evaluation, ECOBIAS). Methodological aspects, study results, and sensitivity analyses were extracted and synthesized to generate a consistent overview of the cost effectiveness of human papillomavirus vaccination in the men-who-have-sex-with-men population. Results: From 770 identified articles, four met the inclusion criteria. Across the studies, human papillomavirus vaccination showed incremental cost-effectiveness ratios ranging from dominant to US$96,146 and US$14,000 to US$18,200 for tertiary prevention and primary prevention, respectively. The incremental cost-effectiveness ratio seemed most sensitive to vaccine efficacy, vaccine costs, and the incidence of anal cancer in the selected target populations. Conclusion: This review presents the human papillomavirus vaccine, both as a primary and adjuvant (tertiary) vaccination, as a potentially cost-effective strategy for preventing mainly—but not limited to only—anal cancer in men-who-have-sex-with-men populations.

Original languageEnglish
Pages (from-to)929-939
Number of pages11
Issue number8
Publication statusPublished - 1 Aug 2018

Bibliographical note

Funding Information:
These findings are the result of work supported by the University of Groningen and Directorate General of Higher Education (DIKTI) Scholarship, Ministry of National Education, Indonesia. The views expressed in this study are solely those of the authors and no official endorsement by both institutions is intended or inferred. Didik Setiawan, Abrham Wondimu, KohJun Ong, Albert Jan van Hoek, and Maarten J. Postma received no financial compensation for their contributions to this work; however, Maarten J. Postma received grants and honoraria from various pharmaceutical companies, including those developing, producing, and marketing human papillomavirus vaccines.


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