This study aims to explore irregular relationships between input and outcomes in cost-effectiveness analysis, accounting for interdependencies between many input parameters. We used a dynamic infectious disease transmission model investigating the cost-effectiveness of varicella and zoster vaccination as a case study. Incremental costs and effects were used separately as the outcomes of interest, rather than the ratio between these, and a single R 2 was calculated for groups of interdependent input parameters. Partial R2 was obtained as measure for the marginal proportion of variance explained. The most important input parameters were related to zoster epidemiology and disease transmission. In case of linear relationships, R 2 is an easy to obtain importance measure, also in the presence of interdependent input parameters.
|Number of pages||2|
|Journal||Procedia - Social and Behavioral Sciences|
|Publication status||Published - 2010|
|Event||6th International Conference on Sensitivity Analysis of Model Output, SAMO 2010 - Milan, Italy|
Duration: 19 Jul 2010 → 22 Jul 2010
- coefficient of determination
- sensitivity measure