Cost-effectiveness of varicella and zoster vaccination in England&Wales: Importance measures for correlated parameters

J. Bilcke*, Albert Jan Van Hoek, N. Hens, M. Aerts, W. J. Edmunds, P. Beutels

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

1 Citation (Scopus)

Abstract

This study aims to explore irregular relationships between input and outcomes in cost-effectiveness analysis, accounting for interdependencies between many input parameters. We used a dynamic infectious disease transmission model investigating the cost-effectiveness of varicella and zoster vaccination as a case study. Incremental costs and effects were used separately as the outcomes of interest, rather than the ratio between these, and a single R 2 was calculated for groups of interdependent input parameters. Partial R2 was obtained as measure for the marginal proportion of variance explained. The most important input parameters were related to zoster epidemiology and disease transmission. In case of linear relationships, R 2 is an easy to obtain importance measure, also in the presence of interdependent input parameters.

Original languageEnglish
Pages (from-to)7611-7612
Number of pages2
JournalProcedia - Social and Behavioral Sciences
Volume2
Issue number6
DOIs
Publication statusPublished - 2010
Event6th International Conference on Sensitivity Analysis of Model Output, SAMO 2010 - Milan, Italy
Duration: 19 Jul 201022 Jul 2010

Keywords

  • coefficient of determination
  • correlation
  • cost-effectiveness
  • dependency
  • sensitivity measure
  • uncertainty

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