Daily testing for contacts of individuals with SARS-CoV-2 infection and attendance and SARS-CoV-2 transmission in English secondary schools and colleges: an open-label, cluster-randomised trial

Bernadette C. Young*, David W. Eyre, Saroj Kendrick, Chris White, Sylvester Smith, George Beveridge, Toby Nonnenmacher, Fegor Ichofu, Joseph Hillier, Sarah Oakley, Ian Diamond, Emma Rourke, Fiona Dawe, Ieuan Day, Lisa Davies, Paul Staite, Andrea Lacey, James McCrae, Ffion Jones, Joseph KellyUrszula Bankiewicz, Sarah Tunkel, Richard Ovens, David Chapman, Vineta Bhalla, Peter Marks, Nick Hicks, Tom Fowler, Susan Hopkins, Lucy Yardley, Tim E.A. Peto

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: School-based COVID-19 contacts in England have been asked to self-isolate at home, missing key educational opportunities. We trialled daily testing of contacts as an alternative to assess whether this resulted in similar control of transmission, while allowing more school attendance. 

Methods: We did an open-label, cluster-randomised, controlled trial in secondary schools and further education colleges in England. Schools were randomly assigned (1:1) to self-isolation of school-based COVID-19 contacts for 10 days (control) or to voluntary daily lateral flow device (LFD) testing for 7 days with LFD-negative contacts remaining at school (intervention). Randomisation was stratified according to school type and size, presence of a sixth form, presence of residential students, and proportion of students eligible for free school meals. Group assignment was not masked during procedures or analysis. Coprimary outcomes in all students and staff were COVID-19-related school absence and symptomatic PCR-confirmed COVID-19, adjusted for community case rates, to estimate within-school transmission (non-inferiority margin <50% relative increase). Analyses were done on an intention-to-treat basis using quasi-Poisson regression, also estimating complier average causal effects (CACE). This trial is registered with the ISRCTN registry, ISRCTN18100261. 

Findings: Between March 18 and May 4, 2021, 204 schools were taken through the consent process, during which three decided not to participate further. 201 schools were randomly assigned (control group n=99, intervention group n=102) in the 10-week study (April 19–May 10, 2021), which continued until the pre-appointed stop date (June 27, 2021). 76 control group schools and 86 intervention group schools actively participated; additional national data allowed most non-participating schools to be included in analysis of coprimary outcomes. 2432 (42·4%) of 5763 intervention group contacts participated in daily contact testing. There were 657 symptomatic PCR-confirmed infections during 7 782 537 days-at-risk (59·1 per 100 000 per week) in the control group and 740 during 8 379 749 days-at-risk (61·8 per 100 000 per week) in the intervention group (intention-to-treat adjusted incidence rate ratio [aIRR] 0·96 [95% CI 0·75–1·22]; p=0·72; CACE aIRR 0·86 [0·55–1·34]). Among students and staff, there were 59 422 (1·62%) COVID-19-related absences during 3 659 017 person-school-days in the control group and 51 541 (1·34%) during 3 845 208 person-school-days in the intervention group (intention-to-treat aIRR 0·80 [95% CI 0·54–1·19]; p=0·27; CACE aIRR 0·61 [0·30–1·23]). 

Interpretation: Daily contact testing of school-based contacts was non-inferior to self-isolation for control of COVID-19 transmission, with similar rates of symptomatic infections among students and staff with both approaches. Infection rates in school-based contacts were low, with very few school contacts testing positive. Daily contact testing should be considered for implementation as a safe alternative to home isolation following school-based exposures. 

Funding: UK Government Department of Health and Social Care.

Original languageEnglish
Pages (from-to)1217-1229
Number of pages13
JournalThe Lancet
Volume398
Issue number10307
Early online date14 Sep 2021
DOIs
Publication statusPublished - 2 Oct 2021

Bibliographical note

Funding Information: This study was funded by the UK Government Department of Health and Social Care and supported by the UK Government Department for Education and Office for National Statistics. The work was also supported by the National Institute for Health Research (NIHR) Health Protection Research Unit (HPRU) in Healthcare Associated Infections and Antimicrobial Resistance at Oxford University in partnership with Public Health England (NIHR200915) and the NIHR Biomedical Research Centre, Oxford. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the NIHR, the Department of Health and Social Care, the Department for Education, the Office for National Statistics, or Public Health England. BCY is an NIHR clinical lecturer. BCY, TEAP, and LY received grants from the Department of Health and Social Care to fund this work. DWE is a Robertson Foundation Fellow. LY is an NIHR Senior Investigator and her research programme is partly supported by NIHR Applied Research Collaboration-West, NIHR HPRU for Behavioural Science and Evaluation, and the NIHR Southampton Biomedical Research Centre.

Open Access: No Open Access licence.


Publisher Copyright: © 2021 Elsevier Ltd. All rights reserved.

Citation: Bernadette C Young, David W Eyre, Saroj Kendrick, Chris White, Sylvester Smith, George Beveridge, Toby Nonnenmacher, Fegor Ichofu, Joseph Hillier, Sarah Oakley, Ian Diamond, Emma Rourke, Fiona Dawe, Ieuan Day, Lisa Davies, Paul Staite, Andrea Lacey, James McCrae, Ffion Jones, Joseph Kelly, Urszula Bankiewicz, Sarah Tunkel, Richard Ovens, David Chapman, Vineta Bhalla, Peter Marks, Nick Hicks, Tom Fowler, Susan Hopkins, Lucy Yardley, Tim E A Peto, Daily testing for contacts of individuals with SARS-CoV-2 infection and attendance and SARS-CoV-2 transmission in English secondary schools and colleges: an open-label, cluster-randomised trial, The Lancet, Volume 398, Issue 10307, 2021,
Pages 1217-1229, ISSN 0140-6736,

DOI: https://doi.org/10.1016/S0140-6736(21)01908-5.

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