Decreased time to treatment initiation for multidrug-resistant tuberculosis patients after use of xpert MTB/RIF Test, Latvia

Helen Stagg, Peter White, Vija Riekstiņa, Andra Cīrule, Ģirts Šķenders, Vaira Leimane, Liga Kuksa, Gunta Dravniece, James Brown, Charlotte Jackson

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Few studies have examined whether the Xpert MTB/RIF test improves time to treatment initiation for persons with multidrug-resistant tuberculosis (MDR TB). We determined the impact of this test in Latvia, where it was introduced in 2010. After descriptive analyses of pulmonary MDR TB patients in Latvia during 2009-2012, time to treatment initiation was calculated, and univariate and multivariable accelerated failure time models were constructed. Univariate results showed strong evidence of an association between having rifampinresistant TB detected by Xpert MTB/RIF and reduced time to treatment initiation versus the test not being used. A multivariable model stratifying by previous TB showed similar results. Our finding that in Latvia, time to treatment initiation was decreased for MDR TB cases that were rifampin-resistant TB by XpertMTB/RIF has implications for the use of this test in other settings with a high burden of MDR TB in which rifampin resistance is highly predictive of MDR TB.

Original languageEnglish
Pages (from-to)482-490
Number of pages9
JournalEmerging Infectious Diseases
Volume22
Issue number3
DOIs
Publication statusPublished - Mar 2016

Fingerprint

Dive into the research topics of 'Decreased time to treatment initiation for multidrug-resistant tuberculosis patients after use of xpert MTB/RIF Test, Latvia'. Together they form a unique fingerprint.

Cite this