Detection of vaccine-induced antibodies to Ebola virus in oral fluid

Teresa Lambe*, Tommy Rampling, Dhan Samuel, Georgina Bowyer, Katie J. Ewer, Navin Venkatraman, Matthew Edmans, Steve Dicks, Adrian V.S. Hill, Richard Tedder, Sarah C. Gilbert

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Blood sampling to assess production of antigen-specific antibodies after immunization is commonly performed, but it presents logistical difficulties for trials carried out during an infectious disease outbreak. In this study, we show that antibodies may be reliably detected in oral fluid collected in aminimally invasive manner without use of sharps. Clinical Trials Registration. NCT02240875.

Original languageEnglish
JournalOpen Forum Infectious Diseases
Volume3
Issue number1
DOIs
Publication statusPublished - 1 Jan 2016

Bibliographical note

Publisher Copyright:
© The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

Keywords

  • Antibodies
  • Ebola vaccine
  • Oral fluid
  • Serology

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