Diabetes mellitus and latent tuberculosis infection: Baseline analysis of a large UK cohort

Charlotte Jackson, Joanna Southern, Ajit Lalvani, Francis Drobniewski, Chris J. Griffiths, Marc Lipman, Graham H. Bothamley, Jonathan J. Deeks, Ambreen Imran, Onn Min Kon, Sithembinkosi Mpofu, Vladyslav Nikolayevskyy, Melanie Rees-Roberts, Alice Sitch, Saranya Sridhar, Chuen Yan Tsou, Hilary Whitworth, Ibrahim Abubakar

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). Binomial regression with a log link was used to estimate crude and adjusted prevalence ratios (PRs) and 95% CIs for the relationship between diabetes mellitus (DM) and LTBI. Adjusted for age, sex, ethnicity, body mass index and the presence of other immunocompromising conditions, DM was associated with a 15% higher prevalence of LTBI (adjusted PR=1.15, 95% CI 1.02 to 1.30, p=0.025). Trial registration number PREDICT is registered on clinicaltrials.gov (NCT01162265)

Original languageEnglish
Pages (from-to)91-94
Number of pages4
JournalThorax
Volume74
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • clinical epidemiology
  • tuberculosis

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