Direct single gene mutational events account for radiation-induced intestinal adenoma yields in ApcMin/+ mice

Michele Ellender*, John Harrison, Alan Edwards, Simon Bouffler, Roger Cox

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Data on the induction of small intestinal tumors, predominantly adenomas, by X radiation in ApcMin/+ mice are reported. Comparison of these incidences with estimates of radiation-induced direct single gene mutation frequencies taken from the literature support the hypothesis that direct mutational loss of Apc+ is the sole requirement for initiation of adenoma. Furthermore, estimates of radiation-induced initiation of adenoma per target stem cell in this animal model are similar to or less than radiation-induced direct somatic gene mutation frequencies. Therefore, while the data reported here do not preclude a role for genomic instability in tumor progression, it is not necessary in this model to postulate the involvement of radiation-induced transmissible genomic instability in initiation of intestinal adenoma.

Original languageEnglish
Pages (from-to)552-556
Number of pages5
JournalRadiation Research
Volume163
Issue number5
DOIs
Publication statusPublished - May 2005

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