Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings

Nicholas A. Feasey, James Hadfield, Karen H. Keddy, Tim Dallman, Jan Jacobs, Xiangyu Deng, Paul Wigley, Lars Barquist Barquist, Gemma C. Langridge, Theresa Feltwell, Simon R. Harris, Alison E. Mather, Maria Fookes, Martin Aslett, Chisomo Msefula, Samuel Kariuki, Calman A. Maclennan, Robert S. Onsare, François Xavier Weill, Simon Le HelloAnthony M. Smith, Michael McClelland, Prerak Desai, Christopher M. Parry, John Cheesbrough, Neil French, Josefina Campos, Jose A. Chabalgoity, Laura Betancor, Katie L. Hopkins, Satheesh Nair, Tom J. Humphrey, Octavie Lunguya, Tristan A. Cogan, Milagritos D. Tapia, Samba O. Sow, Sharon M. Tennant, Kristin Bornstein, Myron M. Levine, Lizeth Lacharme-Lora, Dean B. Everett, Robert A. Kingsley, Julian Parkhill, Robert S. Heyderman, Gordon Dougan, Melita A. Gordon, Nicholas R. Thomson

Research output: Contribution to journalArticlepeer-review

83 Citations (Scopus)

Abstract

An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.

Original languageEnglish
Pages (from-to)1211-1217
Number of pages7
JournalNature Genetics
Volume48
Issue number10
DOIs
Publication statusPublished - 1 Oct 2016

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