Dose–Response Modeling: Extrapolating From Experimental Data to Real-World Populations

Adrian Pratt, Emma Bennett, Joseph Gillard, Stephen Leach, Ian Hall

Research output: Contribution to journalArticlepeer-review

Abstract

Dose–response modeling of biological agents has traditionally focused on describing laboratory-derived experimental data. Limited consideration has been given to understanding those factors that are controlled in a laboratory, but are likely to occur in real-world scenarios. In this study, a probabilistic framework is developed that extends Brookmeyer's competing-risks dose–response model to allow for variation in factors such as dose-dispersion, dose-deposition, and other within-host parameters. With data sets drawn from dose–response experiments of inhalational anthrax, plague, and tularemia, we illustrate how for certain cases, there is the potential for overestimation of infection numbers arising from models that consider only the experimental data in isolation.

Original languageEnglish
Pages (from-to)67-78
Number of pages12
JournalRisk Analysis
Volume41
Issue number1
DOIs
Publication statusPublished - Jan 2021

Keywords

  • Competing-risks framework
  • dose–response modeling
  • quantitative microbial risk assessment

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