Dynamics of HIV type 1 recombination following superinfection

Fransje A. Koning*, Anjna Badhan, Simon Shaw, Martin Fisher, Jean Mbisa, Patricia Cane

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

There are currently few detailed studies describing HIV-1 recombination events or the potential impact of recombination on drug resistance. We describe here the viral recombination dynamics in a drug-naive patient initially infected with a circulating recombinant form 19 (CRF19) virus containing transmitted drug resistance mutations followed by superinfection with "wild-type" subtype B virus. Single genome analysis showed replacement of the primary CRF19 virus by recombinants of the CRF19 virus and the superinfecting subtype B virus. The CRF19/B recombinant virus dominating after superinfection had lost drug resistance mutations and at no time was the superinfecting subtype B variant found to be dominant in blood plasma. Furthermore, the detection of recombinant viruses in seminal plasma indicates the potential for onward transmission of these strains.

Original languageEnglish
Pages (from-to)963-970
Number of pages8
JournalAIDS Research and Human Retroviruses
Volume29
Issue number6
DOIs
Publication statusPublished - 1 Jun 2013

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