Effect of different immunisation schedules on the excretion and reversion of oral poliovaccine strains

P. D. Minor*, G. Dunn, Mary Ramsay, David Brown

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Excretion of live oral poliovaccine and molecular markers of increased virulence in the viruses isolated were examined in children who were either previously immunised with inactivated or live vaccine or were unimmunised. There appeared to be some effect of previous immunisation with either live or killed vaccine at the second dose of live vaccine. Where an effect was seen it took the form of reduced rates of excretion, shorter time periods of excretion and more rapid and complete reversion of the excreted virus. The data are consistent with the view that poliovirus is able to escape the immune pressure in the gut to some extent by improving its general fitness rather than direct evasion of immunity.

Original languageEnglish
Pages (from-to)153-160
Number of pages8
JournalJournal of Medical Virology
Volume75
Issue number1
DOIs
Publication statusPublished - Jan 2005

Keywords

  • Excretion rates
  • IPV vaccination
  • Polio infection
  • Virus adaption

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