Effect of sequence variation in meningococcal PorA outer membrane protein on the effectiveness of a hexavalent PorA outer membrane vesicle vaccine in toddlers and school children

Jamie Findlow, Ann Lowe, Sarah Deane, Paul Balmer, Germie Van Den Dobbelsteen, Maureen Dawson, Nicholas Andrews, Raymond Borrow

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Though meningococcal conjugate vaccines are effective against serogroup C, there is currently no vaccine solution for serogroup B disease. PorA outer membrane protein (OMP) is a potential serogroup B vaccine candidate. A hexavalent PorA outer membrane vesicle (OMV) vaccine has been evaluated in phase I and II trials with promising results. However, considerable sequence variation occurs in the variable regions (VRs) encoding these serosubtypes. By using five wild type P1.19,15 variant strains we examined the serum bactericidal antibody (SBA) titres from sera collected from toddlers and school children pre- and post-vaccination. The numbers of subjects with SBA titres of <4, 4 and ≥8 varied greatly between the different strains. This was also reflected when ≥4-fold rises in SBA titres were examined. This finding in sera from toddlers and school children may have implications for PorA based vaccines.

Original languageEnglish
Pages (from-to)2623-2627
Number of pages5
JournalVaccine
Volume23
Issue number20
DOIs
Publication statusPublished - 8 Apr 2005

Keywords

  • Hexavalent PorA
  • Meningococcal PorA
  • Outer membrane vesicle

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