Effects of Macromolecular Chelators on Intestinal Cadmium Absorption in Mice

Ole Andersen*, Robert Bulman, Jesper Bo Nielsen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Abstract: Suppression of absorption by macromolecular chelators have been successful with several metals. In this paper a series of immobilized chelators ranging from DTPA to S‐containing soft bases have been syntetized and investigated for ability to suppress intestinal uptake of 109Cd2+ in mice. Dextran‐0‐ethyl‐mercaptan, xanthates derived from polysaccharides and polyvinyl alcohol, dithiocarbamates of polyethylene imine and aminoethyl cellulose, and DTPA immobilized on aminopropyl silica were all ineffective. DTPA immobilized on aminoethyl cellulose even enhanced the intestinal uptake. The macromolecular chelators were without extensive effect on organ distribution of absorbed cadmium, except for dithiocarbamate immobilized on polyethylene imine, which enhanced the deposition of cadmium in several organs including the brain. Although the results are discouraging, they indicate that design and synthesis of immobilized vicinal dithio compounds may represent an avenue for development of non‐absorbable chelators with high affinity for cadmium. 1989 Nordic Pharmacological Society

Original languageEnglish
Pages (from-to)216-221
Number of pages6
JournalPharmacology & Toxicology
Volume64
Issue number2
DOIs
Publication statusPublished - Feb 1989

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