Efficacies of LICAM(C) and DTPA for the decorporation of inhaled transportable forms of plutonium and americium from the rat

G. N. Stradling, J. W. Stather, S. A. Gray, J. C. Moody, Michele Ellender, Alan Hodgson

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15 Citations (Scopus)

Abstract

The efficacies of N1, N5, N10, N14-tetrakis (2,3-dihydroxy-4-carboxybenzoyl)-tetra-azatetradecane [LICAM(C)] and diethylenetriaminepenta-acetic acid (DTPA) (30 μmol/kg body wt.) have been investigated for plutonium (Pu) decorporation after inhalation as the nitrate or tributyl phosphate (TBP) complexes and the data compared with those obtained after its intravenous injection as the citrate. The efficacy of removal of americium (Am) inhaled as the nitrate has also been examined The results show that: 1. Whereas LICAM(C) and DTPA were similarly effective for removing Pu from the blood, LICAM(C) was considerably inferior to DTPA when transportable forms of Pu were inhaled. 2. LICAM(C) is ineffective for the decorporation of Am. 3. The optimum treatment regimen for both Pu and Am involved the prompt and repeated administration of DTPA.

Original languageEnglish
Pages (from-to)77-84
Number of pages8
JournalHuman Toxicology
Volume5
Issue number2
DOIs
Publication statusPublished - 1986

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