Efficacies of LICAM(C) and DTPA for the Decorporation of Inhaled Transportable Forms of Plutonium and Americium from the Rat

G. N. Stradling, J. W. Stather, S. A. Gray, J. C. Moody, Michele Ellender, Alan Hodgson

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Abstract

The efficacies of N1, N10 N14-tetrakis (2,3-dihydroxy-4-carboxybenzoyl)-tetra-azatetradecane LICAM(C)] and diethylenetriaminepenta-acetic acid (DTPA) (30 μmol/kg body wt.) have been nvestigated for plutonium (Pu) decorporation after inhalation as the nitrate or tributyl phosphate TBP) complexes and the data compared with those obtained after its intravenous injection as the :itrate. The efficacy of removal of americium (Am) inhaled as the nitrate has also been examined. The results show that: . whereas LICAM(C) and DTPA were similarly effective for removing Pu from the blood, [CAM(C) was considerably inferior to DTPA when transportable forms of Pu were inhaled; LICAM(C) is ineffective for the decorporation of Am; the optimum treatment regimen for both Pu and Am involved the prompt and repeated administration of DTPA.

Original languageEnglish
Pages (from-to)77-84
Number of pages8
JournalHuman & Experimental Toxicology
Volume5
Issue number2
DOIs
Publication statusPublished - Mar 1986

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