Efficacy of Tiron for Enhancing the Excretion of Uranium from the Rat

G. N. Stradling, S. A. Gray, J. C. Moody, Michele Ellender

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Tiron (sodium 4, 5-dihydroxybenzene-1,3-disulphonate) has been suggested as a possible antidote for acute uranium poisoning. In this study, the compound has been administered intraperitoneally to rats in dosages of 30, 300 or 1000 μmol kg-1 at 20, 60 and 180 min after the intratracheal instillation of uranyl nitrate. The amounts of uranium deposited in the lungs of rats were equivalent to intakes by workers of about 12 times the permitted daily limit of 2.5 mg. The average body content of uranium at 5 d after exposure were, respectively, about 100%, 78% and 65% of those in untreated animals. It is concluded that the administration of Tiron is of limited practical value for treatment of uranium exposures not greatly in excess of the permitted intake.

Original languageEnglish
Pages (from-to)195-198
Number of pages4
JournalHuman & Experimental Toxicology
Volume10
Issue number3
DOIs
Publication statusPublished - May 1991

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