Efflux pumps, OprD porin, AmpC β-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients

Maria Tomás, Michel Doumith, Marina Warner, Jane Turton, Alejandro Beceiro, German Bou, David M. Livermore, Neil Woodford

Research output: Contribution to journalArticlepeer-review

93 Citations (Scopus)

Abstract

Expression of ampC, oprD, mexA, mexC, mexE, and mexX was studied in 25 Pseudomonas aeruginosa isolates from cystic fibrosis patients, including 14 isolates of the Liverpool epidemic strain. Overexpressed mexA or ampC and reduced oprD were associated with β-lactam resistance. A specific combination of mexR, nalC, and nalD mutations occurred in 11 Liverpool strain isolates, including 7 with upregulated mexA.

Original languageEnglish
Pages (from-to)2219-2224
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Volume54
Issue number5
DOIs
Publication statusPublished - May 2010

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