Emergence of a multidrug-resistant (ASSuTTm) strain of salmonella enterica serovar typhimurium DT120 in England in 2011 and the use of multiple-locus variable-number tandem-repeat analysis in supporting outbreak investigations

Karthikeyan Paranthaman, Sophie Haroon, Samia Latif, Natalie Vinnyey, Valerie De Souza, William Welfare, Mamoona Tahir, Edward Cooke, Kirsten Stone, Chris Lane, Tansy Peters, Richard Puleston

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

In summer 2011, two outbreaks of a unique, multidrug-resistant strain of Salmonella enterica serovar Typhimurium phage type 120 (DT120) occurred mainly in the Midlands, England. The first outbreak occurred among guests attending a wedding in July 2011 ('Wedding outbreak'), followed by a more geographically dispersed outbreak in August and September 2011 ('Midlands outbreak'). Fifty-one cases were confirmed. Detailed epidemiological and environmental health investigations suggested that pork was the most likely source of both outbreaks. All human samples and one pork sample showed the specific multiple-locus variable-number tandem-repeat analysis (MLVA) profile 3-11-12-NA-0211, with at most two loci variations. Trace-back investigations suggested a link to a butcher's shop and a pig farm in the East Midlands. The investigations highlight the utility of molecular analysis (MLVA) in supporting epidemiological investigations of outbreaks caused by S. Typhimurium DT120. Safe handling and cooking of pork by food business operators and consumers are key interventions to prevent future outbreaks.

Original languageEnglish
Pages (from-to)850-855
Number of pages6
JournalFoodborne pathogens and disease
Volume10
Issue number10
DOIs
Publication statusPublished - 1 Oct 2013

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