Epidemiologic Determinants for Modeling Pneumonic Plague Outbreaks

Raymond Gani, Stephen Leach

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)

Abstract

Pneumonic plague poses a potentially increasing risk to humans in plague nonendemic regions either as a consequence of an aerosolized release or through importation of the disease. Pneumonic plague is person-to-person transmissible. We provide a quantitative assessment of transmissibility based on past outbreaks that shows that the average number of secondary cases per primary case (R0) was 1.3 (variance = 3.1), assuming a geometric probability distribution, prior to outbreak control measures. We also show that the latent and infectious periods can be approximated by using lognormal distributions with means (SD) of 4.3 (1.8) and 2.5 (1.2) days. Based on this parameter estimation, we construct a Markov-chain epidemic model to demonstrate the potential impact of delays in implementing outbreak control measures and increasing numbers of index cases on the incidence of cases in simulated outbreaks.

Original languageEnglish
Pages (from-to)608-614
Number of pages7
JournalEmerging Infectious Diseases
Volume10
Issue number4
DOIs
Publication statusPublished - Apr 2004

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