EULAR recommendations for vaccination in paediatric patients with rheumatic diseases

M. W. Heijstek, L. M. Ott De Bruin, M. Bijl, Raymond Borrow, F. Van Der Klis, I. Koné-Paut, A. Fasth, K. Minden, A. Ravelli, M. Abinun, G. S. Pileggi, M. Borte, N. M. Wulffraat

Research output: Contribution to journalArticlepeer-review

151 Citations (Scopus)

Abstract

Evidence-based recommendations for vaccination of paediatric patients with rheumatic diseases (PaedRD) were developed by following the EULAR standardised procedures for guideline development. The EULAR task force consisted of (paediatric) rheumatologists/immunologists, one expert in vaccine evaluation, one expert in public health and infectious disease control, and one epidemiologist. A systematic literature review was conducted in MEDLINE, EMBASE, and abstracts of the EULAR and American College of Rheumatology meetings of 2008/9. The level of evidence and strength of recommendation were based on customary scoring systems. Delphi voting was applied to assess the level of agreement between task force members. 107 papers and eight abstracts were used. The majority of papers considered seasonal influenza (41) or pneumococcal (23) vaccination. 26 studies were performed specifically in paediatric patients, and the majority in adult rheumatoid arthritis and systemic lupus erythematosus patients. Fifteen recommendations were developed with an overall agreement of 91.7%. More research is needed on the safety and immunogenicity of (live-attenuated) vaccination in PaedRD, particularly in those using biologicals, and the effect of vaccination on prevention of infections.

Original languageEnglish
Pages (from-to)1704-1712
Number of pages9
JournalAnnals of the Rheumatic Diseases
Volume70
Issue number10
DOIs
Publication statusPublished - Oct 2011

Fingerprint

Dive into the research topics of 'EULAR recommendations for vaccination in paediatric patients with rheumatic diseases'. Together they form a unique fingerprint.

Cite this