Evaluation of a measles vaccine campaign by oral-fluid surveys in a rural Kenyan district: Interpretation of antibody prevalence data using mixture models

E. O. Ohuma*, E. A. Okiro, A. Bett, J. Abwao, S. Were, Dhanraj Samuel, Andrew Vyse, Nigel Gay, David Brown, D. J. Nokes

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

We evaluated the effectiveness of a measles vaccine campaign in rural Kenya, based on oral-fluid surveys and mixture-modelling analysis. Specimens were collected from 886 children aged 9 months to 14 years pre-campaign and from a comparison sample of 598 children aged 6 months post-campaign. Quantitative measles-specific antibody data were obtained by commercial kit. The estimated proportions of measles-specific antibody negative in children aged 0-4, 5-9 and 10-14 years were 51%, 42% and 27%, respectively, pre- campaign and 18%, 14% and 6%, respectively, post-campaign. We estimate a reduction in the proportion susceptible of 65-78%, with ∼85% of the population recorded to have received vaccine. The proportion of 'weak' positive individuals rose from 35% pre-campaign to 54% post-campaign. Our results confirm the effectiveness of the campaign in reducing susceptibility to measles and demonstrate the potential of oral-fluid studies to monitor the impact of measles vaccination campaigns.

Original languageEnglish
Pages (from-to)227-233
Number of pages7
JournalEpidemiology and Infection
Volume137
Issue number2
DOIs
Publication statusPublished - 2009

Keywords

  • Campaign vaccination
  • Kenya
  • Measles antibodies
  • Mixture modelling
  • Oral fluid

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