Fatal S. aureus hemorrhagic pneumonia: Genetic analysis of a unique clinical isolate producing both PVL and TSST-1

Zhi Li*, Dennis L. Stevens, Stephanie M. Hamilton, Tanyalak Parimon, Yongsheng Ma, Angela Kearns, Richard W. Ellis, Amy E. Bryant

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

In 2008, an unusual strain of methicillin-sensitive Staphylococcus aureus (MSSA68111), producing both Panton-Valentine leukocidin (PVL) and toxic shock syndrome toxin-1 (TSST-1), was isolated from a fatal case of necrotizing pneumonia. Because PVL/TSST-1 co-production in S. aureus is rare, we characterized the molecular organization of these toxin genes in strain 68111. MSSA68111 carries the PVL genes within a novel temperate prophage we call FΦPVLv68111 that is most similar, though not identical, to phage FΦPVL - a phage type that is relatively rare worldwide. The TSST-1 gene (tst) in MSSA68111 is carried on a unique staphylococcal pathogenicity island (SaPI) we call SaPI68111. Features of SaPI68111 suggest it likely arose through multiple major recombination events with other known SaPIs. Both FΦPVLv68111 and SaPI68111 are fully mobilizable and therefore transmissible to other strains. Taken together, these findings suggest that hypervirulent S. aureus have the potential to emerge worldwide.

Original languageEnglish
Article numbere27246
JournalPLoS ONE
Volume6
Issue number11
DOIs
Publication statusPublished - 3 Nov 2011

Fingerprint

Dive into the research topics of 'Fatal S. aureus hemorrhagic pneumonia: Genetic analysis of a unique clinical isolate producing both PVL and TSST-1'. Together they form a unique fingerprint.

Cite this