Filovirus neutralising antibodies: Mechanisms of action and therapeutic application

Alexander Hargreaves, Caolann Brady, Jack Mellors, Tom Tipton, Miles W. Carroll, Stephanie Longet*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

Filoviruses, especially Ebola virus, cause sporadic outbreaks of viral haemorrhagic fever with very high case fatality rates in Africa. The 2013–2016 Ebola epidemic in West Africa provided large survivor cohorts spurring a large number of human studies which showed that specific neutralising antibodies played a key role in protection following a natural Ebola virus infection, as part of the overall humoral response and in conjunction with the cellular adaptive response. This review will discuss the studies in survivors and animal models which described protective neutralising antibody response. Their mechanisms of action will be detailed. Furthermore, the importance of neutralising antibodies in antibody-based therapeutics and in vaccine-induced responses will be explained, as well as the strategies to avoid immune escape from neutralising antibodies. Understanding the neutralising antibody response in the context of filoviruses is crucial to furthering our understanding of virus structure and function, in addition to improving current vaccines & antibody-based therapeutics.

Original languageEnglish
Article number1201
JournalPathogens
Volume10
Issue number9
DOIs
Publication statusPublished - 16 Sep 2021

Bibliographical note

Funding Information: The APC was funded by the US Food and Drug Administration (grant number: 75F40120C 00085).

Open Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Citation: Hargreaves, A.; Brady, C.; Mellors, J.; Tipton, T.; Carroll, M.W.; Longet, S. Filovirus Neutralising Antibodies: Mechanisms of Action and Therapeutic Application. Pathogens 2021, 10, 1201.

DOI: https://doi.org/10.3390/pathogens10091201

Keywords

  • Ebolavirus
  • Filoviruses
  • Longitudinal antibody response
  • Monoclonal antibodies
  • Neutralising antibodies
  • Post-infection
  • Post-vaccination

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