Genomic and phenotypic variability in neisseria gonorrhoeae antimicrobial susceptibility, England

Katy Town, Simon Harris, Leonor Sánchez-Busó, Michelle Cole, Rachel Pitt-Kendall, Helen Fifer, Hamish Mohammed, Nigel Field, Gwenda Hughes

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a global concern. Phylogenetic analyses resolve uncertainties regarding genetic relatedness of isolates with identical phenotypes and inform whether AMR is due to new mutations and clonal expansion or separate introductions by importation. We sequenced 1,277 isolates with associated epidemiologic and antimicrobial susceptibility data collected during 2013-2016 to investigate N. gonorrhoeae genomic variability in England. Comparing genetic markers and phenotypes for AMR, we identified 2 N. gonorrhoeae lineages with different antimicrobial susceptibility profiles and 3 clusters with elevated MICs for ceftriaxone, varying mutations in the penA allele, and different epidemiologic characteristics. Our results indicate N. gonorrhoeae with reduced antimicrobial susceptibility emerged independently and multiple times in different sexual networks in England, through new mutation or recombination events and by importation. Monitoring and control for AMR in N. gonorrhoeae should cover the entire population affected, rather than focusing on specific risk groups or locations.

Original languageEnglish
Pages (from-to)505-515
Number of pages11
JournalEmerging Infectious Diseases
Volume26
Issue number3
DOIs
Publication statusPublished - 4 Feb 2020

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