Global population structure and evolution of Bordetella pertussis and their relationship with vaccination

Marieke J. Bart, Simon R. Harris, Abdolreza Advani, Yoshichika Arakawa, Daniela Bottero, Valérie Bouchez, Pamela K. Cassiday, Chuen Sheue Chiang, Tine Dalby, Norman Fry, María Emilia Gaillard, Marjolein van Gent, Nicole Guiso, Hans O. Hallander, Eric T. Harvill, Qiushui He, Han G.J. van der Heide, Kees Heuvelman, Daniela F. Hozbor, Kazunari KamachiGennady I. Karataev, Ruiting Lan, Anna Lutyńska, Ram P. Maharjan, Jussi Mertsola, Tatsuo Miyamura, Sophie Octavia, Andrew Preston, Michael A. Quail, Vitali Sintchenko, Paola Stefanelli, M. Lucia Tondella, Raymond S.W. Tsang, Yinghua Xu, Shu Man Yao, Shumin Zhang, Julian Parkhill, Frits R. Mooi

Research output: Contribution to journalArticlepeer-review

158 Citations (Scopus)

Abstract

Bordetella pertussis causes pertussis, a respiratory disease that is most severe for infants. Vaccination was introduced in the 1950s, and in recent years, a resurgence of disease was observed worldwide, with significant mortality in infants. Possible causes for this include the switch from whole-cell vaccines (WCVs) to less effective acellular vaccines (ACVs), waning immunity, and pathogen adaptation. Pathogen adaptation is suggested by antigenic divergence between vaccine strains and circulating strains and by the emergence of strains with increased pertussis toxin production. We applied comparative genomics to a worldwide collection of 343 B. pertussis strains isolated between 1920 and 2010. The global phylogeny showed two deep branches; the largest of these contained 98% of all strains, and its expansion correlated temporally with the first descriptions of pertussis outbreaks in Europe in the 16th century. We found little evidence of recent geographical clustering of the strains within this lineage, suggesting rapid strain flow between countries. We observed that changes in genes encoding proteins implicated in protective immunity that are included in ACVs occurred after the introduction of WCVs but before the switch to ACVs. Furthermore, our analyses consistently suggested that virulence-associated genes and genes coding for surface-exposed proteins were involved in adaptation. However, many of the putative adaptive loci identified have a physiological role, and further studies of these loci may reveal less obvious ways in which B. pertussis and the host interact. This work provides insight into ways in which pathogens may adapt to vaccination and suggests ways to improve pertussis vaccines.

Original languageEnglish
Article numbere01074-14
JournalmBio
Volume5
Issue number2
DOIs
Publication statusPublished - 22 Apr 2014

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