Global verification of a model for determining daylight photodynamic therapy dose

Paul O'Mahoney, Marina Khazova, Ethan LaRochelle, Brian Pogue, Sally H. Ibbotson, Ewan Eadie

Research output: Contribution to journalArticlepeer-review

Abstract

Daylight photodynamic therapy is an effective treatment for actinic keratoses and relies on a minimum PpIX-effective light exposure dose being delivered during treatment. As such, daylight dosimetry is an important aspect of this treatment. Relatively simple measurements of illuminance may be converted to PpIX-effective irradiance, and subsequently exposure dose, via a conversion model (the O'Mahoney model). This model has been verified against spectral irradiance data from the UK, however the accuracy of the model has not been determined outside the UK. In this work, we test the O'Mahoney model against spectral irradiance measurements from several global locations to within bounds of a median deviation of ±10 %. The median percentage deviations are shown to be independent of location latitude and longitude. The model can be used confidently to determine PpIX-effective irradiance from illuminance measurements irrespective of location and can be widely implemented as an effective and low-cost means of accurately measuring effective light exposure for this important treatment.

Original languageEnglish
Article number102260
JournalPhotodiagnosis and Photodynamic Therapy
Volume34
Early online date26 Mar 2021
DOIs
Publication statusE-pub ahead of print - 26 Mar 2021

Keywords

  • Actinic keratosis
  • DPDT
  • Daylight
  • Dosimetry
  • Irradiance
  • Photodynamic therapy

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